Endoscopy — Cystoscopy & Ureteroscopy
Cystoscopy and ureteroscopy are diagnostic, therapeutic and surveillance tools in reconstructive urology, from preoperative planning and intraoperative quality assurance to postoperative surveillance and endoscopic management of complications.
Part I: Cystoscopy in reconstructive surgery
Role 1 — Intraoperative injury detection during pelvic reconstructive surgery
The 2018 AUGS consensus calls for cystoscopy during all prolapse reconstructive operations except isolated posterior repairs; a 2026 systematic review’s Delphi statements call for cystoscopy during uterosacral ligament suspension, while its expert opinion suggests selective use for isolated anterior colporrhaphy, particularly with advanced anterior defects.[1][2][53] This is supported by several findings:
- In a historical 224-patient series, unsuspected injury occurred in 9 patients (4%).[3]
- Intraoperative cystoscopy should inspect the bladder and urethra for injury and confirm bilateral ureteral efflux.[1] For uterosacral ligament suspension during primary uterovaginal prolapse repair, a 2026 Delphi consensus says to repeat cystoscopy after sutures are tied if an earlier check was performed under tension.[53] Dyes can aid visualization; select the formulation and route according to its safety profile and local protocol. Visible jets assess patency at that time and do not exclude every partial or delayed thermal injury.[1][2] The distension fluid itself is also a choice: 10% or 50% dextrose is nonconductive, and observers rated ureteric jets clearer with 50% dextrose than with normal saline in a small blinded video comparison.[50][51] Against that visualization benefit, a retrospective cohort found more postoperative UTI with 10% dextrose than normal saline (47.8% vs 25.9%), with transient glucosuria proposed as the mechanism; this favors weighing the infection signal when choosing fluid.[50][51]
- A review reports that identifying and treating injuries intraoperatively is associated with decreased morbidity, lower healthcare costs and lower litigation risk than delayed detection.[2]
- A technical report describes transabdominal power Doppler visualization of ureteral jets as an alternative check of ureteral patency during gynecologic surgery, with cystoscopy when jets are absent, diminished or not seen.[4]
- When marked anterior or apical prolapse obscures the cystoscopic view, a vaginal sponge stick can reduce the prolapse and restore the vesicourethral angle, improving visualization of the ureteral orifices.[52]
- Suprapubic telescopy has been described as an alternative when the lower urinary tract needs evaluation during open abdominal pelvic surgery: after closing the anterior peritoneum, the bladder is filled retrogradely through a three-lumen Foley, an absorbable purse-string suture is placed through the detrusor at the dome, and a stab incision inside the suture admits a 30-degree telescope; tightening the purse-string limits leakage while the scope moves, and Foley-supplied distension means no separate sheath or bridge is needed.[49] This author-described technique has no comparative safety or outcome data.[49]
Role 2 — Cystoscopy-assisted techniques during ureteral reimplantation
Cystoscopy plays a direct technical role during certain reimplantation procedures. In a two-patient technical report, Chung et al. described laparoscopic ureteroneocystostomy with psoas hitch using cystoscopy-assisted submucosal tunneling: cystoscopic injection of normal saline into the submucosal plane facilitates creation of the anti-reflux tunnel during minimally invasive reimplantation.[5]
The separate question of screening cystoscopy before pediatric reimplantation for primary reflux was studied retrospectively in 128 children in 2001. One unsuspected ureterocele was found, in a child with incomplete bladder imaging, and no operative plan changed. The reported 16.2% cost increment was institution- and era-specific. This supports questioning low-yield screening when imaging is adequate.[6]
Part II: Cystoscopy for postoperative surveillance
Role 3 — Surveillance after urethroplasty
Cystoscopy is a component of postoperative surveillance after urethroplasty and detects stricture recurrence directly.[7][8] The EAU 2026 guideline recommends at least one year of follow-up , flexible cystoscopy at three months , and later surveillance adjusted to recurrence risk , with flow and patient-reported measures in its risk-based protocols.[45]
The AUA Urethral Stricture Disease Guideline advises monitoring to identify symptomatic recurrence after dilation, direct vision internal urethrotomy or urethroplasty . Its text states that urethrocystoscopy, urethral ultrasound or retrograde urethrography, alone or combined, appears to provide the most definitive confirmation of recurrence, and that no specific lumen diameter has been shown to be diagnostic of recurrence.[7] Evidence on cystoscopic surveillance:
- Goonesinghe et al. prospectively followed 144 post-urethroplasty patients with flexible urethroscopy at 3, 6, and 12 months and annually thereafter. 26 of 27 recurrences requiring treatment were detected in the first year. Flow data were available in only 11 of those 27; seven exceeded 15 mL/s.[9] Thin diaphragms and more substantial restenosis were described.[9]
- Amend et al. (TURNS multi-institutional study, 304 patients, median 64-month follow-up) reported that early surveillance urethroscopy findings predicted long-term outcomes. Secondary intervention was performed in 64% of patients with small-caliber (<17 Fr) recurrences, 18.3% of those with lumens ≥17 Fr and 15% of those with normal lumens.[10]
- Baradaran et al. (TURNS, 1054 patients) found that many patients with cystoscopic recurrence do not ultimately need intervention; at median 350-day follow-up, 33.8% of small-caliber recurrences and 6.2% of large-caliber recurrences required secondary procedures.[11] Quality of life was not significantly different among groups.[11]
Among 142 GURS survey respondents, 111 used objective follow-up testing and 64 of those 111 (57.7%) used cystoscopy.[12]
Recurrence surveillance and leak assessment are separate questions. Calvo and Rourke compared 100 bulbar urethroplasty patients with VCUG against 100 matched controls without imaging and found no significant difference in 90-day complications or recurrence. EAU guidance states that extravasation should be assessed before catheter removal, by pericatheter retrograde urethrography, retrograde urethrography or VCUG, and that low-grade ("wisp-like") extravasation does not appear to affect the long-term restricture rate.[45] Subsequent follow-up is tailored to repair type and recurrence risk; see RUG/VCUG.[13][45]
A bulbar stricture that recurs unusually quickly, or has an irregular, moth-eaten appearance on cystoscopy or urethrography, in a middle-aged or older patient should raise concern for primary urethral malignancy and prompt biopsy; this is an expert caution, not a validated prediction rule, and an irregular contour alone is not a cancer diagnosis.[48]
Role 4 — Surveillance after bladder augmentation: malignancy screening
The role of routine surveillance cystoscopy after augmentation cystoplasty remains controversial, with conflicting recommendations:[14][15][16][17]
Arguments for surveillance:
- A systematic review of mostly low-quality reports found malignancy proportions ranging 0–5.5% with mean latency around 19 years. Adenocarcinoma is the most common type (51.6%), predominantly at the entero-urinary anastomosis.[15]
- Soergel et al. reported 3 patients with TCC after AC for neuropathic bladder, all of whom died of metastatic disease, and recommended endoscopic surveillance beginning 10 years after surgery.[17]
- Garnier et al. found that 13 of 16 patients with post-AC malignancy were diagnosed at advanced stage, with only 56% 1-year survival.[18]
- A small prospective FISH study enrolled 36 patients; 24 received FISH testing, 32 underwent biopsy, and only two cancers were found. Its reported 100% sensitivity and 95% specificity are too imprecise and selectively verified to establish a routine screening strategy.[19]
Arguments against routine surveillance:
- Hamid et al. prospectively evaluated 92 patients with enterocystoplasty (median follow-up 15 years): no cancer was identified by screening cystoscopy; 53 patients also consented to biopsies. The only malignancy was diagnosed in a symptomatic patient who had previously had a normal surveillance cystoscopy.[14]
- Higuchi et al. enrolled 65 patients at least 10 years after augmentation; 50 remained on protocol. During the first five surveillance years, 250 cytologies and 250 endoscopies found no malignancy. Routine endoscopy and cytology was then discontinued while annual clinical assessment continued.[16]
- Kokorowski et al. (decision analysis) found annual screening cystoscopy and cytology after AC in spina bifida patients had only an 11% chance of being cost-effective at a $100,000 / life-year threshold.[20]
- Higuchi et al. (matched cohort) found no significant difference in bladder-cancer incidence between augmented patients and matched controls with congenital bladder dysfunction (4.6% versus 2.6%, p=0.54).[21]
Guideline-based follow-up. For adult NLUTD patients with bowel-segment urinary reconstruction, AUA/SUFU recommends annual history and examination, metabolic testing, and urinary-tract imaging.[22] Its Statement 60 recommends cystoscopy for gross hematuria or symptomatic recurrent UTI after bowel reconstruction, and Statements 19 and 20 (Strong Recommendations, Grade B) advise against screening or surveillance cystoscopy in NLUTD, including with a chronic indwelling catheter.[22][59] The Statement 58 annual bundle is an Expert Opinion.[22] The guideline text adds that hematuria, unexplained recurrent UTI or suprapubic pain should prompt full evaluation, including cystoscopy, cytology and CT. Continue lifelong reconstruction follow-up even when scheduled cancer-screening cystoscopy is omitted.[22][14]
Gastric segments need individualized specialist review. A historical series reported two metastatic cancers among 72 gastrocystoplasty patients and its authors advocated annual cystoscopy and biopsy.[23]
Role 5 — Cystoscopy for bladder neck contracture and VUAS
Cystoscopy is the diagnostic reference and the therapeutic platform for BNC and VUAS. A large prostatectomy registry used symptoms plus inability to pass a 17 Fr cystoscope to define VUAS for that study.[7][24]
Cystoscopy serves as the vehicle for all endoscopic treatments:
- Direct vision internal urethrotomy (DVIU) with cold knife or holmium laser can treat selected nonobliterative posterior stenosis. During DVIU for VUAS or radiation-induced bulbomembranous stenosis, avoid deep 6 and 12 o’clock incisions because of rectal injury and urosymphyseal fistulation, respectively ; counsel about new or worsened incontinence .[25][45]
- Balloon dilation is an option for selected nonobliterative posterior stenosis. Do not use endoluminal treatment for completely obliterated VUAS, bulbomembranous stenosis or bladder neck stenosis .[45]
- Intralesional adjuncts have been described, but posterior MMC injection has caused rare severe necrosis, osteitis pubis, and fistula. The EAU 2026 guideline advises that MMC for nontraumatic posterior urethral stenosis be used only within a clinical trial.[45] See antimitotic/antifibrotic agents.[25][26]
- Transurethral incision with transverse mucosal realignment. A cystoscopic technique using a laparoscopic suturing device transurethrally to bring healthy bladder mucosa across the defect (analogous to an endoscopic Y-V plasty), with 89% 17-Fr cystoscope passage at four months after one procedure and 100% after two in an initial 19-patient retrospective series (median follow-up six months). Long-term durability and comparative benefit remain uncertain.[27]
Rozanski et al. retrospectively studied 86 patients: composite success (17-Fr cystoscope passage without catheterization or additional procedures) was 65% after one treatment and 90% after repeat treatments overall, with 94% in nonradiated versus 76% in radiated patients (median follow-up 21.1 months).[26]
Part III: Ureteroscopy in reconstructive surgery
Role 6 — Diagnostic evaluation of ureteral strictures
Ureteroscopy can clarify an uncertain ureteral lesion and facilitate selected treatment. Combine it with imaging of the stricture and renal unit; an impassable lumen limits what can be inspected. If upper-tract malignancy is suspected and imaging/cytology are insufficient, diagnostic ureteroscopy can support diagnosis and risk assessment.[47]
For ureteral strictures specifically, ureteroscopy allows:
- Direct visualization of stricture morphology, length, and degree of obliteration.
- Targeted tissue biopsy when malignancy is a concern. Small samples may miss disease or undergrade or understage it; a negative biopsy does not automatically prove a benign stricture.[47]
- Assessment of mucosal quality proximal and distal to the stricture.
- Guidewire passage to determine whether the stricture is traversable.
Role 7 — Endoscopic treatment of benign ureteral strictures
Endoscopic management is a first-line option for selected ureteral strictures, although Ou et al. describe reconstruction as the gold standard for definitive management:[28][29][30]
| Technique | Selection and evidence | Main limitation |
|---|---|---|
| Balloon dilation | Best results in selected short (≤2 cm), nonobliterative strictures; a 19-series meta-analysis found 89% technical success, 60% at three months and 54% at 6–12 months. Onset within 3 months showed a nonsignificant trend to better results[30] | Ischemic/long strictures fare less well |
| Endoureterotomy | Can treat selected short benign strictures; Razdan reported 74% overall success among 50 endoscopically treated patients with ureteral strictures of mixed causes, including malignant and ureteroenteric strictures; a separate mixed balloon-dilation and/or laser-incision series reported 29/34 (85%) endoscopic success[29][31] | Ischemia is not itself an indication favoring incision |
| Balloon dilation + endoureterotomy | Some retrospective distal-ureter series report better outcomes with combination treatment | No established universal superiority; selection and treatment protocols differ |
| Endoluminal Allium stent after incision/dilation | Gao's 25-patient series reported 23/25 successes at median 12 months[33] | Called “ureteric bypass” by the authors; this is endoluminal stenting, not an extra-anatomic bypass. Limited durability data |
Comparison with reconstruction. Ou et al. retrospectively compared 95 endoscopically treated and 47 reconstructed patients: success (symptomatic improvement and radiographic relief of obstruction) was 51.6% versus 95.7% (p<0.01).[28] Treatment selection was not randomized.[28]
In that cohort, short proximal or distal strictures and mild-to-moderate hydronephrosis were favorable endoscopic features; reported median time to recurrence after endourological treatment was 51 months. Select treatment individually and continue follow-up because recurrence can be delayed.[28]
Role 8 — Endoscopic management of ureteroenteric anastomotic strictures
Ureteroscopy plays a role in managing ureteroenteric anastomotic strictures (UEAS) after urinary diversion, for which Katims et al. cite a 3–10% incidence.[35][36][37][38] In a retrospective robot-assisted radical cystectomy cohort, 51 patients (13%) developed UEAS; estimated cumulative incidence was 19% at five years:[55]
Antegrade approach (via percutaneous nephrostomy tract). In a multi-institutional robotic-revision cohort after cystectomy, 4 of 58 affected renal units had malignant strictures; evaluate suspicious narrowing with imaging, cytology and targeted biopsy when indicated before endoscopic treatment.[56][47] Katims et al. described a technique of antegrade flexible ureteroscopy with biopsy, followed by laser incision, triamcinolone injection, balloon dilation to 24 Fr, and temporary parallel double-J stents or upside-down nephrostomy tubes, with 20/24 strictures patent in 21 patients at median 30-month follow-up.[35] The small Katims single-arm series cannot isolate steroid injection's contribution or yield a general success rate.[35]
Retrograde approach (through the conduit or neobladder). More challenging due to altered anatomy and absence of standard landmarks. Costamagna et al. described using a side-viewing duodenoscope to access the ureteroileal anastomosis in Bricker conduits, achieving initial technical success in 19/24 complications among 17 patients. Fourteen successfully treated patients were followed; some still required stents.[39]
Combined antegrade-retrograde approach. Delvecchio et al. described this in five patients: an antegrade nephrostogram provides better anatomical delineation, while through-and-through access enables rapid identification of stenotic segments hidden by mucosal folds and allows use of larger endoscopes with better irrigation.[40]
Endoscopic versus open revision. Van Son et al. retrospectively evaluated 76 patients receiving 161 procedures (26 open, 135 endoscopic) over a 27-year period and found that at 60 months, patency rates were 69% after open revision versus 27% after endoscopic treatment (p=0.003), with median patency duration of 15.5 versus 5 months.[37] Endoscopic treatment can defer revision in selected patients; a 2026 meta-analysis found greater laser success for ureteroenteric strictures <1 cm.[54] A 2026 systematic review of first-time treatment for benign ureteroenteric strictures in adults included 31 studies (858 patients); seven comparative cohorts (368 renal units) found higher primary patency after open revision than endoscopic treatment (RR 2.31, 95% CI 1.54–3.47), with more minor complications after open revision.[54] Success definitions and patient selection varied substantially.[54] Results vary: another series found 20/28 UEAS successfully treated at median 25 months.[36]
Role 9 — Stone management in reconstructed urinary tracts
Ureteroscopy and cystoscopy are used in managing urolithiasis, one of the most common long-term complications of urinary reconstruction:
- Reported cumulative stone incidence after augmentation is 28–36% at 10 years. Among adults with bladder augmentation who have previously formed stones, reported recurrence is 15–44%.[46]
- Antegrade flexible ureteroscopy is one option when diversion anatomy limits retrograde access. In Stuurman et al.'s small series of 17 patients/21 procedures (15 stone procedures and six stricture procedures), 80% of patients treated for stones were stone-free after the first antegrade session.[41]
- The antegrade approach is used when retrograde access is impossible or extremely difficult because of altered anatomy (continent pouches, neobladders with afferent limbs).
- Reservoir stone access must protect the urethra and continence channel. EAU notes that channel instrumentation can damage its continence mechanism; percutaneous or open removal is often preferred when safe natural-orifice access is unavailable.[46]
Role 10 — Ureteroscopy as a cause of ureteral strictures: iatrogenic considerations
Ureteroscopy is associated with ureteral stricture, which reconstructive surgeons may be asked to repair:[42][43]
- Sunaryo et al. studied 329,776 patients treated with ureteroscopy, shock-wave lithotripsy, or both. Stricture was coded in 2.9% of the ureteroscopy group versus 1.5% of the lithotripsy-only group (adjusted OR 1.71). SWL was a treated comparator, not an untreated stone-only control. Of those with strictures after ureteroscopy, 35% required drainage, 21% had endoscopic intervention, 4.8% required reconstructive surgery, and 1.7% underwent nephrectomy.[43]
- Ulvik et al. performed 1001 ureteroscopies in 725 patients; among 995 analyzable cases, 28 strictures were found on CT at three months. Independent risk factors included ureteral access sheath use (OR 4.6), ureteral perforation (OR 11.8), and operative time >60 minutes (OR 5.7).[42]
- In the Ulvik series, dilation succeeded in 15/20 treated strictures in a selected subset.[42]
A 43-study meta-analysis of adult urolithiasis treatments estimated post-ureteroscopy ureteral stricture rates of 1.9% overall and 4.9% with impacted stones; preoperative hydronephrosis, intraoperative perforation and stone impaction were associated with higher stricture odds after endoscopic treatment.[58] These observational associations support careful access, avoidance of force and perforation, and reassessment of difficult or prolonged procedures. Sheath choice should reflect anatomy, pressure and irrigation needs, and the procedure.
Part IV: Endoscopy in catheterizable channel management
Role 11 — Evaluating and treating channel complications
Cystoscopy through catheterizable channels is used in managing the most common complications:
- Stomal or deeper channel stenosis. Cystoscopy through the channel identifies the level and severity of stenosis, guides dilation, and determines whether open revision is needed.
- False passage formation. Endoscopic evaluation identifies the false tract and true lumen and guides catheter placement. In adults without a patent urethral outlet, failed channel catheterization requires emergent intervention; a pediatric cystoscope or ureteroscope can assess suspected channel trauma.[57]
- Channel incontinence. Endoscopy may identify a structural problem, but cannot alone distinguish channel failure from an unsafe or overfilled reservoir; assess storage and emptying as well.
- Reservoir stones. Choose access that preserves the channel. Avoid forcing a scope or instrument through resistance; larger burdens may require percutaneous or open removal.[46]
Part V: Endoscopy in gender-affirming reconstruction
Role 12 — Managing neourethral complications after phalloplasty
Endoscopy contributes to evaluation of suspected urethral complications after phalloplasty. Reported fistula and stricture rates vary substantially by technique, follow-up, and source of outcome reporting; alternate cohorts in a review covering phalloplasty and metoidioplasty reported fistula rates of 39.5–56.4% and stricture rates of 31.8–65.5%. Endoscopic assessment identifies:[44]
- Stricture location (most commonly at the pars fixa–pars pendulans junction).
- Fistula tracts and their relationship to the neourethra.
- Diverticula within the neourethra.
- Stone formation within the neourethral segment.
For selected short, nonobliterative anastomotic strictures, incision may be considered after tissue healing. EAU advises against incision or urethroplasty in the first six months after neophalloplasty and against more than two endoscopic incisions except palliation. Significant early obstruction may require suprapubic drainage; involve a reconstructive team familiar with the neourethral anatomy.[45]
Summary table — roles of cystoscopy and ureteroscopy in reconstructive surgery
| Clinical context | Endoscopic role | Principle | Refs |
|---|---|---|---|
| Pelvic reconstructive surgery | Intraoperative cystoscopy to confirm ureteral efflux | AUGS consensus statement: universal cystoscopy (except posterior-compartment-only operations) | 1, 2 |
| Post-urethroplasty surveillance | Flexible cystoscopy at 3, 6 and 12 months in one prospective series | Small-caliber (<17 Fr) recurrence predicts need for reintervention | 9, 10, 11 |
| Post-augmentation cystoplasty | Cystoscopy for symptoms or concerning findings; screening remains debated | AUA/SUFU advises against routine screening in adult NLUTD and recommends cystoscopy for gross hematuria or symptomatic recurrent UTI after bowel reconstruction; review gastric segments individually[22] | 14, 15, 16, 22, 23 |
| BNC / VUAS | Diagnosis, dilation, or incision when indicated | MMC is not routine; EAU advises it be used within clinical trials[45] | 7, 24–27, 45 |
| Ureteral strictures | Diagnostic ureteroscopy + endoureterotomy / dilation | Endoscopic outcomes are better in selected strictures ≤2 cm; reconstruction had higher overall success in a retrospective comparison | 28, 29, 30 |
| Ureteroenteric strictures | Selected antegrade, retrograde, or combined treatment | Heterogeneous case-series outcomes; consider durable reconstruction and renal preservation | 35–40 |
| Stones in reconstructed tracts | Antegrade URS or cystoscopic lithotripsy | Choose access by stone burden/anatomy; protect continence channels | 41 |
| Catheterizable channel complications | Cystoscopy through channel | Defines anatomy; assess reservoir function and avoid channel injury | — |
| Post-phalloplasty neourethral complications | Cystoscopy / urethroscopy | Identifies stricture location, fistula, diverticula | 44 |
| Iatrogenic stricture prevention | Meticulous ureteroscopic technique | Risk associations inform careful technique | 42, 43 |
See Also
- Urethral Stricture Disease. Diagnostic and surveillance framework.
- Upper Tract Reconstruction. Definitive repair options for ureteral strictures that fail endoscopic management.
- Bladder Neck Reconstruction. Open or robotic salvage after endoscopic failure.
- Urinary Diversion. Anatomic substrate for ureteroenteric stricture endoscopy.
- Endoureterotomy and Drug-Coated Balloon Therapy. Endoscopic ureteral-treatment technique pages.
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