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Christopher R. Chapple

Christopher R. Chapple

🇬🇧 United Kingdom🏥 Royal Hallamshire Hospital, Sheffield, UK
▶ Videos (3)
Mentored by
Richard Turner-Warwick

Training and career​

  • Current position Emeritus consultant urological surgeon, Sheffield Teaching Hospitals; honorary professor, University of Sheffield; visiting professor, Sheffield Hallam University1
  • Medical school Middlesex Hospital Medical School (medical degree, 1980)2
  • Fellowship Period visiting US reconstructive units2
  • Other training Surgical training, Birmingham; subsequent training, Middlesex Hospital, with Euan Milroy and Richard Turner-Warwick2
  • Leadership Secretary general, European Association of Urology (2015–2023)13

Key Publications​

Chapple's cited work covers male and female urethral reconstruction, including graft augmentation and substitution urethroplasty. Other confirmed papers examine overactive and underactive bladder treatment, assessment, and terminology.P3P4P5P6P7

  1. Bhargava S, Patterson JM, Inman RD, et al. "Tissue-Engineered Buccal Mucosa Urethroplasty—Clinical Outcomes." European Urology. 2008;53(6):1263–1271. doi

    Tissue-engineered buccal mucosa urethroplasty series (2008). Senior-authored a clinical series reporting use of tissue-engineered buccal mucosa grafts for substitution urethroplasty.

    Cited on: Liquid / Minced Buccal Mucosal Graft
  2. Chapple CR, Kaplan SA, Mitcheson D, et al. "Randomized Double-blind, Active-controlled Phase 3 Study to Assess 12-Month Safety and Efficacy of Mirabegron, a β3-Adrenoceptor Agonist, in Overactive Bladder." European Urology. 2013;63(2):296–305. doi

    Twelve-month mirabegron phase 3 trial (2013). First-authored a randomized phase 3 study comparing twelve-month mirabegron treatment with tolterodine for overactive bladder.

  3. Mangera A, Patterson JM, Chapple CR. "A Systematic Review of Graft Augmentation Urethroplasty Techniques for the Treatment of Anterior Urethral Strictures." Eur Urol. 2011;59(5):797-814. doi
    Cited on: Quilting Stitch · Asopa Dorsal Inlay OMG Urethroplasty · Palminteri Double-Face (Two-Sided) BMG Urethroplasty
  4. Patterson JM, Chapple CR. Surgical techniques in substitution urethroplasty using buccal mucosa for the treatment of anterior urethral strictures. Eur Urol. 2008;53(6):1162-1171. doi
    Cited on: Combined Dorsal BMG + Ventral Fasciocutaneous Flap (Erickson) · Staged BMG Urethroplasty (Female) · Dorsal Onlay Oral Mucosal Graft Urethroplasty
  5. Osman NI, Mangera A, Chapple CR. A systematic review of surgical techniques used in the treatment of female urethral stricture. Eur Urol. 2013;64(6):965-973. doi
    Cited on: Distal Urethrectomy with Advancement Meatoplasty (Female) · Female DVIU and Urethral Dilation · Labia Minora Pedicled Flap (Female Urethroplasty)
  6. Chapple C, Sievert KD, MacDiarmid S, et al. "OnabotulinumtoxinA 100 U significantly improves all idiopathic overactive bladder symptoms and quality of life in patients with overactive bladder and urinary incontinence: a randomised, double-blind, placebo-controlled trial." Eur Urol. 2013;64(2):249–256. doi
    Cited on: Botulinum Toxin (Neuromodulation Adjunct) · Botulinum Toxin (OnabotulinumtoxinA & Variants)
  7. Abdel-Fattah M, Chapple C, Cooper D, et al. "Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial." Lancet. 2025;405(10484):1057–1068. doi
    Cited on: Mixed Urinary Incontinence · Urgency Incontinence & OAB

Other Publications Cited on WARWIKI

29 additional publications with Christopher R. Chapple as a listed author are cited on WARWIKI, ordered by the number of pages that cite them. Papers whose author list is shortened to "et al." before this name are not included.

  1. Pang KH, Chapple CR, Chatters R, et al. "A systematic review and meta-analysis of adjuncts to minimally invasive treatment of urethral stricture in men." Eur Urol. 2021;80(4):467–479. doi
    Cited on: Antimitotics and Antifibrotics · Intralesional Corticosteroids · DVIU and Urethral Dilation
  2. Aldamanhori RB, Osman NI, Inman RD, Chapple CR. Contemporary outcomes of hypospadias retrieval surgery in adults. BJU Int. 2018;122(4):673-679. doi
    Cited on: Redo Hypospadias Repair in Adolescents and Adults · Hypospadias & Epispadias · Transitional Urology
  3. Hillary CJ, Osman NI, Hilton P, Chapple CR. "The aetiology, treatment, and outcome of urogenital fistulae managed in well- and low-resourced countries: a systematic review." Eur Urol. 2016;70(3):478–492. doi
    Cited on: Urethroperineal Fistula · Urethrovaginal Fistula Repair · Urethroperineal Fistula Repair
  4. Reeves FA, Inman RD, Chapple CR. Management of symptomatic urethral diverticula in women: a single-centre experience. Eur Urol. 2014;66(1):164-172. doi
    Cited on: Female Urethral & Periurethral Masses · Urethral Diverticulum · Urethral Diverticulectomy
  5. Gratzke C, van Maanen R, Chapple C, et al. "Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II)." Eur Urol. 2018;74(4):501–509. doi
    Cited on: Anticholinergic / Antimuscarinic Agents · β3-Adrenergic Receptor Agonists
  6. Fusco F, Abdel-Fattah M, Chapple CR, et al. "Updated Systematic Review and Meta-Analysis of the Comparative Data on Colposuspensions, Pubovaginal Slings, and Midurethral Tapes in the Surgical Treatment of Female Stress Urinary Incontinence." Eur Urol. 2017;72(4):567-591. doi
    Cited on: Female Slings & Suspensions · Transobturator Mid-Urethral Sling
  7. Drake MJ, Chapple C, Esen AA, et al. "Efficacy and safety of mirabegron add-on therapy to solifenacin in incontinent overactive bladder patients with an inadequate response to initial 4-week solifenacin monotherapy: a randomised double-blind multicentre phase 3b study (BESIDE)." Eur Urol. 2016;70(1):136-145. doi
    Cited on: Anticholinergic / Antimuscarinic Agents · β3-Adrenergic Receptor Agonists
  8. Kuo TL, Venugopal S, Inman RD, Chapple CR. Surgical tips and tricks during urethroplasty for bulbar urethral strictures focusing on accurate localisation of the stricture: results from a tertiary centre. Eur Urol. 2015;67(4):764-770. doi
    Cited on: Methylene Blue · Principles of Urethral Reconstruction
  9. Chapple C, Abrams P, Lam T, et al. A consensus statement on when to start clean intermittent self-catheterization: an untapped resource? Neurourol Urodyn. 2024;43(2):459-463. doi
    Cited on: Intermittent Catheters and Clean Intermittent Catheterization (CIC)
  10. Saad S, Osman N, Alsulaiman OA, Chapple CR. Surgical Repair of Urethral Diverticula. In: Martins FE, Holm HV, Sandhu JS, McCammon KA, eds. Female Genitourinary and Pelvic Floor Reconstruction. Springer; 2023:857-867.
    Cited on: Urethral Diverticulectomy
  11. Chapple C, Kelleher C, Siddiqui E, et al. Validation of the overactive bladder-bladder assessment tool (OAB-BAT): a potential alternative to the standard bladder diary for monitoring OAB outcomes. Eur Urol Focus. 2021;7(5):1176-1183. doi
    Cited on: Assessment Tools & Questionnaires
  12. Osman NI, Bratt DG, Downey AP, Esperto F, Inman RD, Chapple CR. "A systematic review of surgical interventions for the treatment of bladder pain syndrome/interstitial cystitis." Eur Urol Focus. 2021;7(4):877-885. doi
    Cited on: Interstitial Cystitis / Bladder Pain Syndrome

Footnotes​

  1. Academy of Europe: CV. Accessed October 2026. ↩ ↩2

  2. 20250227085040_51843.pdf. Accessed October 2026. ↩ ↩2 ↩3

  3. The EAU has a new Secretary General. Uroweb. Accessed October 2026. ↩