Intraurethral Alprostadil (MUSE)

The Medicated Urethral System for Erection (MUSE) delivers a small alprostadil (prostaglandin E1) pellet into the urethra via a prefilled applicator. The drug is absorbed through the urethral mucosa into the corpus spongiosum and diffuses into the corpora cavernosa, producing smooth muscle relaxation and erection independent of neurogenic stimulation. Efficacy is approximately 40–65%, lower than intracavernosal injection but with less invasiveness.

Indications

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Technique Overview

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Key Steps

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Outcomes & Evidence

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References

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